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第 5 期 陈平 等：不同饮食模式对 CUMS 诱导的小鼠焦虑抑郁样行为的影响 205

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Effects of different dietary patterns on anxiety and depression-like

behavior induced by CUMS in mice

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CHEN Ping ,LI Xiaofang ,YU Ying ,ZHANG Yingying ,ZHANG Jiaming ,LI Chunmei ,LI Kaikai 1,2
1.College of Food Science and Technology，Huazhong Agricultural University，Wuhan 430070，China；
2.Key Laboratory of Environment Correlative Dietology，Ministry of Education，
Huazhong Agricultural University，Wuhan 430070，China
Abstract Chronic unpredictability mild stress（CUMS）model was used to investigate the effects of

different dietary patterns on anxiety and depression-like behaviors in mice.C57BL/6 mice were randomly di⁃
vided into normal diet group（ND），normal diet stress group（NDS），high fat diet group（HFD）and high
fat diet stress group（HFDS）.The behavior，body weight，lipid profiles and neurotransmitters of mice were
measured.The results showed that compared with the ND group，the sucrose preference of HFD group was
significantly decreased，and the total movement distance，the number of entering the central area and the
number of crossing squares were decreased in the open field test.Some behavioral indexes of HFDS group
were lower than those of HFD group，and some behavioral indexes in HFDS group were lower than those
in NDS group.The body weight，adipose/weight，TC and TG levels of HFD group were higher than those
of the other groups，and CUMS significantly reduced the adipose/weight，TC and TG levels of the high-fat
diet and normal diet mice，and these lipid indexes were lower in HFDS group than in NDS group.The con⁃
tents of 5-HT and NE in HFD group were lower than those in ND group.CUMS significantly decreased
the levels of 5-HT and NE in serum and hippocampus of high-fat diet and normal diet mice，and the levels
of neurotransmitters in HFDS group were lower than that in NDS group.The results suggested that high-fat
diet can easily induce anxiety and depression-like behaviors，and aggravate CUMS-induced anxiety and de⁃
pression behaviors，which may be related to lipid metabolism and central neurotransmitter metabolism path⁃
ways.
Keywords chronic unpredictability mild stress（CUMS）；dietary pattern；behavior；anxiety and de⁃
pression；lipid；neurotransmitters

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